Assay Detail
Binding
CHEMBL4480512
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Inhibition of ovine COX1 using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition and measured after 2 mins by ELISA
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rationally synthesized coumarin based pyrazolines ameliorate carrageenan induced inflammation through COX-2/pro-inflammatory cytokine inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.71 | 4.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4519601 | — | — | 1 | 4.79 |
| CHEMBL1258748 | — | — | 1 | 4.70 |
| CHEMBL1258747 | — | — | 1 | 4.65 |
| CHEMBL4483384 | — | — | 1 | - |
| CHEMBL4531675 | — | — | 1 | - |
| CHEMBL1258869 | — | — | 1 | - |
| CHEMBL4589730 | — | — | 1 | - |
| CHEMBL416146 | ETORICOXIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4519601 | — | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL1258748 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL1258747 | — | IC50 | = | 22400.0 | nM | 4.65 |
| CHEMBL4483384 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4531675 | — | IC50 | - | — | - | |
| CHEMBL1258869 | — | IC50 | - | — | - | |
| CHEMBL4589730 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL416146 | ETORICOXIB | IC50 | > | 30000.0 | nM | - |