Assay Detail
Binding
CHEMBL4480627
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DPCPX from adenosine A1 receptor in rat brain membranes by radioligand competition assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membranes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Methoxy substituted 2-benzylidene-1-indanone derivatives as A1 and/or A2A AR antagonists for the potential treatment of neurological conditions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 6.71 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | — | 1 | 9.40 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 8.17 |
| CHEMBL4572336 | — | — | 1 | 7.39 |
| CHEMBL4523006 | — | — | 1 | 7.38 |
| CHEMBL4547939 | — | — | 1 | 6.36 |
| CHEMBL4527335 | — | — | 1 | 6.02 |
| CHEMBL4535634 | — | — | 1 | 5.79 |
| CHEMBL4541726 | — | — | 1 | 5.78 |
| CHEMBL4580228 | — | — | 1 | 5.48 |
| CHEMBL4559281 | — | — | 1 | 5.37 |
| CHEMBL4569263 | — | — | 1 | - |
| CHEMBL4570432 | — | — | 1 | - |
| CHEMBL4577288 | — | — | 1 | - |
| CHEMBL3902894 | — | — | 1 | - |
| CHEMBL1906073 | — | — | 1 | - |
| CHEMBL28855 | — | — | 1 | - |
| CHEMBL4552783 | — | — | 1 | - |
| CHEMBL4572298 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL4572336 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL4523006 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL4547939 | — | Ki | = | 435.0 | nM | 6.36 |
| CHEMBL4527335 | — | Ki | = | 956.0 | nM | 6.02 |
| CHEMBL4535634 | — | Ki | = | 1620.0 | nM | 5.79 |
| CHEMBL4541726 | — | Ki | = | 1650.0 | nM | 5.78 |
| CHEMBL4580228 | — | Ki | = | 3280.0 | nM | 5.48 |
| CHEMBL4559281 | — | Ki | = | 4290.0 | nM | 5.37 |
| CHEMBL4569263 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL4570432 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL4577288 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL3902894 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL1906073 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL28855 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL4552783 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL4572298 | — | Ki | > | 100000.0 | nM | - |