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Compound Detail

CHEMBL4535634

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O=C1/C(=C/c2cccc(O)c2)CCc2c(O)cccc21

Basic Information

ChEMBL ID CHEMBL4535634
Phase Preclinical
Structure Type MOL
InChI Key QUVXBPVTGLXVTR-FMIVXFBMSA-N
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

266.3
MW (Da)
3.31
ALogP
3
HBA
2
HBD
57.5
PSA (Ų)
0.78
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C17H14O3
MW 266.30
Aromatic Rings 2
Heavy Atoms 20
NP-Likeness 0.47

Activity Summary

Ki 4 meas. best 5.79

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adrenergic receptor alpha-1
CHEMBL1907610
Ki 5.79 5.79 1620.0 1
Adenosine receptor A1
CHEMBL318
Ki 5.79 5.79 1620.0 1
Adenosine receptor A2a
CHEMBL302
Ki 5.26 5.26 5460.0 1
Alpha-2A adrenergic receptor
CHEMBL327
Ki 5.26 5.26 5460.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
30881617 10.1039/C8MD00540K Adenosine receptor A1 1
30881617 10.1039/C8MD00540K Adenosine receptor A2a 1
35932905 10.1016/j.bmcl.2022.128921 RAW264.7 1
34743062 10.1016/j.ejmech.2021.113964 Adrenergic receptor alpha-1 1
34743062 10.1016/j.ejmech.2021.113964 Alpha-2A adrenergic receptor 1
34743062 10.1016/j.ejmech.2021.113964 Unchecked 1

Data from ChEMBL 36 via Core Engine