Assay Detail
Binding
CHEMBL4480643
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes measured after 120 mins by scintillation counting analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sigma non-opioid intracellular receptor 1 (CHEMBL4153) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Synthesis and receptor binding of thiophene bioisosteres of potent GluN2B ligands with a benzo[7]annulene-scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.69 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4574247 | — | — | 1 | 7.10 |
| CHEMBL305187 | IFENPRODIL | 2.0 | 1 | 6.90 |
| CHEMBL4287203 | — | — | 1 | 6.88 |
| CHEMBL4590193 | — | — | 1 | 6.78 |
| CHEMBL4570472 | — | — | 1 | 6.33 |
| CHEMBL4513837 | — | — | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4574247 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL305187 | IFENPRODIL | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL4287203 | — | Ki | = | 132.0 | nM | 6.88 |
| CHEMBL4590193 | — | Ki | = | 167.0 | nM | 6.78 |
| CHEMBL4570472 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL4513837 | — | Ki | = | 737.0 | nM | 6.13 |