Assay Detail
Binding
CHEMBL4481774
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]CCPA from rat adenosine A2a receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel multi-target directed ligands based on annelated xanthine scaffold with aromatic substituents acting on adenosine receptor and monoamine oxidase B. Synthesis, in vitro and in silico studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.12 | 8.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431770 | ISTRADEFYLLINE | 4.0 | 1 | 8.36 |
| CHEMBL241618 | — | — | 1 | 6.10 |
| CHEMBL4517303 | — | — | 1 | 5.05 |
| CHEMBL4544530 | — | — | 1 | 4.52 |
| CHEMBL113 | CAFFEINE | 4.0 | 1 | 4.49 |
| CHEMBL4569183 | — | — | 1 | 4.48 |
| CHEMBL4579508 | — | — | 1 | 4.39 |
| CHEMBL4530654 | — | — | 1 | 4.38 |
| CHEMBL4483563 | — | — | 1 | 4.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431770 | ISTRADEFYLLINE | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL241618 | — | Ki | = | 802.0 | nM | 6.10 |
| CHEMBL4517303 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL4544530 | — | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL113 | CAFFEINE | Ki | = | 32500.0 | nM | 4.49 |
| CHEMBL4569183 | — | Ki | = | 33000.0 | nM | 4.48 |
| CHEMBL4579508 | — | Ki | = | 41000.0 | nM | 4.39 |
| CHEMBL4530654 | — | Ki | = | 42000.0 | nM | 4.38 |
| CHEMBL4483563 | — | Ki | = | 52000.0 | nM | 4.28 |