Assay Detail
Binding
CHEMBL4603707
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Inhibition of human amyloid beta (1 to 40) aggregation after 24 hrs by ThT fluorescence assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Isolation of three new meroterpenoids and seven known compounds from Albatrellus yasudae and their Aβ-aggregation inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.64 | 5.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL164 | MYRICETIN | — | 1 | 5.13 |
| CHEMBL4638539 | — | — | 1 | 4.91 |
| CHEMBL4640668 | — | — | 1 | 4.78 |
| CHEMBL4641877 | — | — | 1 | 4.70 |
| CHEMBL513978 | GRIFOLIC ACID | — | 1 | 4.69 |
| CHEMBL1171643 | DAURICHROMENIC ACID | — | 1 | 4.61 |
| CHEMBL4646459 | — | — | 1 | 4.53 |
| CHEMBL2012313 | CEREBROSIDE | — | 1 | 4.20 |
| CHEMBL4645437 | — | — | 1 | 4.17 |
| CHEMBL4643713 | — | — | 1 | - |
| CHEMBL4644047 | — | — | 1 | - |
| CHEMBL487804 | GRIFOLIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL164 | MYRICETIN | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4638539 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL4640668 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL4641877 | — | IC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL513978 | GRIFOLIC ACID | IC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL1171643 | DAURICHROMENIC ACID | IC50 | = | 24700.0 | nM | 4.61 |
| CHEMBL4646459 | — | IC50 | = | 29300.0 | nM | 4.53 |
| CHEMBL2012313 | CEREBROSIDE | IC50 | = | 62700.0 | nM | 4.20 |
| CHEMBL4645437 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL4643713 | — | IC50 | = | 221000.0 | nM | - |
| CHEMBL4644047 | — | IC50 | = | 150800.0 | nM | - |
| CHEMBL487804 | GRIFOLIN | IC50 | = | 148800.0 | nM | - |