Compound Detail
CHEMBL1171643
DAURICHROMENIC ACID Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL1171643 |
| Name | DAURICHROMENIC ACID |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UYLFTJMQPWWDCW-MVLVPLOLSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
370.5
MW (Da)
6.04
ALogP
3
HBA
2
HBD
66.8
PSA (Ų)
0.57
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 7.82
IC50 1 meas. best 4.61
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Human immunodeficiency virus 1 CHEMBL378 | EC50 | 7.82 | 7.82 | 15.0 | 1 |
| Amyloid-beta precursor protein CHEMBL2487 | IC50 | 4.61 | 4.61 | 24700.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Human immunodeficiency virus 1 | EC50 | = | 15.0 | nM | 7.82 | Antiviral activity against HIV1 3B infected in H9 cells assessed as inhibition o... | 20187635 |
| Amyloid-beta precursor protein | IC50 | = | 24700.0 | nM | 4.61 | Inhibition of human amyloid beta (1 to 40) aggregation after 24 hrs by ThT fluor... | 31791817 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20187635 | 10.1021/np900821e | Human immunodeficiency virus 1 | 1 |
| 20187635 | 10.1021/np900821e | ADMET | 1 |
| 31791817 | 10.1016/j.bmcl.2019.126808 | Amyloid-beta precursor protein | 1 |
| 27494166 | 10.1016/j.ejmech.2016.07.057 | Human immunodeficiency virus 1 | 1 |
| 27494166 | 10.1016/j.ejmech.2016.07.057 | H9 | 1 |
| 27494166 | 10.1016/j.ejmech.2016.07.057 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine