Assay Detail
ADMET
CHEMBL4604696
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate incubated for 12 min in presence of NADPH by LC-MS/MS analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Development of 3-(6-Chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]hexane Hydrochloride (SUVN-911): A Novel, Potent, Selective, and Orally Active Neuronal Nicotinic Acetylcholine α4β2 Receptor Antagonist for the Treatment of Depression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.48 | 4.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4641810 | — | — | 1 | 4.77 |
| CHEMBL4643942 | — | — | 1 | 4.58 |
| CHEMBL4643543 | — | — | 1 | 4.52 |
| CHEMBL4649507 | — | — | 1 | 4.49 |
| CHEMBL4642118 | — | — | 1 | 4.42 |
| CHEMBL4642287 | — | — | 1 | 4.10 |
| CHEMBL4645127 | — | — | 1 | - |
| CHEMBL4638732 | — | — | 1 | - |
| CHEMBL4642865 | — | — | 1 | - |
| CHEMBL4645367 | — | — | 1 | - |
| CHEMBL4636163 | — | — | 1 | - |
| CHEMBL4647198 | — | — | 1 | - |
| CHEMBL4641432 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4641810 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL4643942 | — | IC50 | = | 26200.0 | nM | 4.58 |
| CHEMBL4643543 | — | IC50 | = | 30200.0 | nM | 4.52 |
| CHEMBL4649507 | — | IC50 | = | 32100.0 | nM | 4.49 |
| CHEMBL4642118 | — | IC50 | = | 38100.0 | nM | 4.42 |
| CHEMBL4642287 | — | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL4645127 | — | IC50 | > | 42000.0 | nM | - |
| CHEMBL4638732 | — | IC50 | > | 45000.0 | nM | - |
| CHEMBL4642865 | — | IC50 | > | 45000.0 | nM | - |
| CHEMBL4645367 | — | IC50 | > | 45000.0 | nM | - |
| CHEMBL4636163 | — | IC50 | > | 45000.0 | nM | - |
| CHEMBL4647198 | — | IC50 | > | 45000.0 | nM | - |
| CHEMBL4641432 | — | IC50 | > | 45000.0 | nM | - |