Assay Detail
ADMET
CHEMBL4604697
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 2 min in presence of NADPH by LC-MS/MS analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Development of 3-(6-Chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]hexane Hydrochloride (SUVN-911): A Novel, Potent, Selective, and Orally Active Neuronal Nicotinic Acetylcholine α4β2 Receptor Antagonist for the Treatment of Depression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.59 | 4.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4636163 | — | — | 1 | 4.68 |
| CHEMBL4643543 | — | — | 1 | 4.50 |
| CHEMBL4643942 | — | — | 1 | - |
| CHEMBL4645127 | — | — | 1 | - |
| CHEMBL4638732 | — | — | 1 | - |
| CHEMBL4642118 | — | — | 1 | - |
| CHEMBL4642865 | — | — | 1 | - |
| CHEMBL4641810 | — | — | 1 | - |
| CHEMBL4645367 | — | — | 1 | - |
| CHEMBL4649507 | — | — | 1 | - |
| CHEMBL4647198 | — | — | 1 | - |
| CHEMBL4642287 | — | — | 1 | - |
| CHEMBL4641432 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4636163 | — | IC50 | = | 21100.0 | nM | 4.68 |
| CHEMBL4643543 | — | IC50 | = | 31900.0 | nM | 4.50 |
| CHEMBL4643942 | — | IC50 | > | 45000.0 | nM | - |
| CHEMBL4645127 | — | IC50 | > | 45000.0 | nM | - |
| CHEMBL4638732 | — | IC50 | > | 45000.0 | nM | - |
| CHEMBL4642118 | — | IC50 | > | 45000.0 | nM | - |
| CHEMBL4642865 | — | IC50 | > | 45000.0 | nM | - |
| CHEMBL4641810 | — | IC50 | > | 45000.0 | nM | - |
| CHEMBL4645367 | — | IC50 | > | 45000.0 | nM | - |
| CHEMBL4649507 | — | IC50 | > | 45000.0 | nM | - |
| CHEMBL4647198 | — | IC50 | > | 45000.0 | nM | - |
| CHEMBL4642287 | — | IC50 | > | 45000.0 | nM | - |
| CHEMBL4641432 | — | IC50 | > | 45000.0 | nM | - |