Assay Detail
ADMET
CHEMBL4605648
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant CYP3A4 expressed in insect cell microsomes in presence of NADPH by fluorescence assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Accelerated Discovery of Novel Ponatinib Analogs with Improved Properties for the Treatment of Parkinson's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.20 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL255863 | NILOTINIB | 4.0 | 1 | 6.24 |
| CHEMBL4633367 | — | — | 1 | 5.34 |
| CHEMBL4640297 | — | — | 1 | 5.25 |
| CHEMBL4638981 | — | — | 1 | 5.14 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 4.94 |
| CHEMBL4632471 | — | — | 1 | 4.93 |
| CHEMBL4637502 | — | — | 1 | 4.87 |
| CHEMBL4642144 | — | — | 1 | 4.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL255863 | NILOTINIB | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL4633367 | — | IC50 | = | 4610.0 | nM | 5.34 |
| CHEMBL4640297 | — | IC50 | = | 5580.0 | nM | 5.25 |
| CHEMBL4638981 | — | IC50 | = | 7280.0 | nM | 5.14 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL4632471 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL4637502 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL4642144 | — | IC50 | = | 13400.0 | nM | 4.87 |