Assay Detail
ADMET
CHEMBL4606494
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate measured after 10 mins by LC-MS/MS analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimizing Pyrazolopyrimidine Inhibitors of Calcium Dependent Protein Kinase 1 for Treatment of Acute and Chronic Toxoplasmosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 4.30 | 4.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4634455 | — | — | 1 | 4.30 |
| CHEMBL4646408 | — | — | 1 | 4.30 |
| CHEMBL4642579 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4634455 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL4646408 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL4642579 | — | EC50 | = | 50000.0 | nM | 4.30 |