Assay Detail
Functional
CHEMBL4610779
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human THP1 cells assessed as reduction in cell viability incubated for 72 hrs by cell titer glo assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.77 | 6.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4640303 | — | — | 1 | 6.09 |
| CHEMBL4647911 | — | — | 1 | 5.78 |
| CHEMBL4636103 | — | — | 1 | 5.76 |
| CHEMBL4633500 | — | — | 1 | 5.74 |
| CHEMBL4637198 | — | — | 1 | 5.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4640303 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4647911 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL4636103 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL4633500 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL4637198 | — | IC50 | = | 3260.0 | nM | 5.49 |