Assay Detail
Binding
CHEMBL4611051
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Agonist activity at TLR7 in mouse RAW264.7 cells assessed as immunostimulatory activity by measuring increase in TNFalpha secretion incubated for 18 hrs by ELISA
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and immunostimulatory activity of sugar-conjugated TLR7 ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 6.83 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4635169 | — | — | 1 | 7.40 |
| CHEMBL4635551 | — | — | 1 | 7.24 |
| CHEMBL4641702 | — | — | 1 | 7.10 |
| CHEMBL4636482 | — | — | 1 | 6.97 |
| CHEMBL4639831 | — | — | 1 | 6.89 |
| CHEMBL4636020 | — | — | 1 | 6.88 |
| CHEMBL4645661 | — | — | 1 | 6.87 |
| CHEMBL4632609 | — | — | 1 | 6.82 |
| CHEMBL4641619 | — | — | 1 | 6.64 |
| CHEMBL4640564 | — | — | 1 | 6.63 |
| CHEMBL4637769 | — | — | 1 | 6.60 |
| CHEMBL4647035 | — | — | 1 | 6.60 |
| CHEMBL4647802 | — | — | 1 | 6.54 |
| CHEMBL4639099 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4635169 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4635551 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4641702 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4636482 | — | EC50 | = | 107.0 | nM | 6.97 |
| CHEMBL4639831 | — | EC50 | = | 128.0 | nM | 6.89 |
| CHEMBL4636020 | — | EC50 | = | 132.0 | nM | 6.88 |
| CHEMBL4645661 | — | EC50 | = | 136.0 | nM | 6.87 |
| CHEMBL4632609 | — | EC50 | = | 153.0 | nM | 6.82 |
| CHEMBL4641619 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4640564 | — | EC50 | = | 234.0 | nM | 6.63 |
| CHEMBL4637769 | — | EC50 | = | 252.0 | nM | 6.60 |
| CHEMBL4647035 | — | EC50 | = | 252.0 | nM | 6.60 |
| CHEMBL4647802 | — | EC50 | = | 287.0 | nM | 6.54 |
| CHEMBL4639099 | — | EC50 | = | 316.0 | nM | 6.50 |