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Compound Detail

CHEMBL4637769

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COCCOc1nc(N)c2[nH]c(=O)n(Cc3ccc(C(=O)O)cc3)c2n1

Basic Information

ChEMBL ID CHEMBL4637769
Phase Preclinical
Structure Type MOL
InChI Key ATISKRYGYNSRNP-UHFFFAOYSA-N
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

359.3
MW (Da)
0.47
ALogP
8
HBA
3
HBD
145.3
PSA (Ų)
0.52
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H17N5O5
MW 359.34
Aromatic Rings 3
Heavy Atoms 26
NP-Likeness -0.84

Activity Summary

EC50 4 meas. best 6.6

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Toll-like receptor 7
CHEMBL6085
EC50 6.6 6.0775 252.0 4

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
31864800 10.1016/j.bmcl.2019.126840 Toll-like receptor 7 6
30351939 10.1021/acs.jmedchem.8b00960 Bone marrow cell 2
30351939 10.1021/acs.jmedchem.8b00960 CD4+ve Th 1

Data from ChEMBL 36 via Core Engine