Assay Detail
Binding
CHEMBL4611053
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Agonist activity at TLR7 in mouse BMDC cells assessed as immunostimulatory activity by measuring increase in IL6 secretion incubated for 18 hrs by ELISA
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and immunostimulatory activity of sugar-conjugated TLR7 ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 6.90 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4635551 | — | — | 1 | 7.57 |
| CHEMBL4635169 | — | — | 1 | 7.40 |
| CHEMBL4636482 | — | — | 1 | 7.25 |
| CHEMBL4639831 | — | — | 1 | 7.15 |
| CHEMBL4645661 | — | — | 1 | 7.00 |
| CHEMBL4636020 | — | — | 1 | 6.97 |
| CHEMBL4641702 | — | — | 1 | 6.96 |
| CHEMBL4647802 | — | — | 1 | 6.82 |
| CHEMBL4641619 | — | — | 1 | 6.70 |
| CHEMBL4632609 | — | — | 1 | 6.68 |
| CHEMBL4640564 | — | — | 1 | 6.62 |
| CHEMBL4639099 | — | — | 1 | 6.59 |
| CHEMBL4647035 | — | — | 1 | 6.52 |
| CHEMBL4637769 | — | — | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4635551 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4635169 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4636482 | — | EC50 | = | 56.0 | nM | 7.25 |
| CHEMBL4639831 | — | EC50 | = | 71.0 | nM | 7.15 |
| CHEMBL4645661 | — | EC50 | = | 99.0 | nM | 7.00 |
| CHEMBL4636020 | — | EC50 | = | 108.0 | nM | 6.97 |
| CHEMBL4641702 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4647802 | — | EC50 | = | 153.0 | nM | 6.82 |
| CHEMBL4641619 | — | EC50 | = | 198.0 | nM | 6.70 |
| CHEMBL4632609 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4640564 | — | EC50 | = | 239.0 | nM | 6.62 |
| CHEMBL4639099 | — | EC50 | = | 258.0 | nM | 6.59 |
| CHEMBL4647035 | — | EC50 | = | 303.0 | nM | 6.52 |
| CHEMBL4637769 | — | EC50 | = | 434.0 | nM | 6.36 |