Assay Detail
Binding
CHEMBL4611057
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Agonist activity at TLR7 in mouse RAW264.7 cells assessed as immunostimulatory activity by measuring increase in TNFalpha secretion preincubated with actin polymerization inhibitor cytochalasin D followed by incubation with compound for 6 hrs by ELISA
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and immunostimulatory activity of sugar-conjugated TLR7 ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.98 | 6.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4645661 | — | — | 1 | 6.23 |
| CHEMBL4641619 | — | — | 1 | 6.04 |
| CHEMBL4635551 | — | — | 1 | 5.97 |
| CHEMBL4637769 | — | — | 1 | 5.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4645661 | — | EC50 | = | 585.0 | nM | 6.23 |
| CHEMBL4641619 | — | EC50 | = | 909.0 | nM | 6.04 |
| CHEMBL4635551 | — | EC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL4637769 | — | EC50 | = | 2110.0 | nM | 5.68 |