Assay Detail
Functional
CHEMBL4611519
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Antiviral activity against Zika virus infected in African green monkey Vero E6 cells assessed as reduction in viral induced cytopathic effect
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Zika virus |
| Cell Type | Vero C1008 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of novel 4-amino-2-(4-benzylpiperazin-1-yl)methylbenzonitrile compounds as Zika inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.16 | 5.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4637514 | — | — | 1 | 5.36 |
| CHEMBL4637078 | — | — | 1 | 5.31 |
| CHEMBL4636374 | — | — | 1 | 5.29 |
| CHEMBL4648991 | — | — | 1 | 5.28 |
| CHEMBL4634271 | — | — | 1 | 5.25 |
| CHEMBL1643 | RIBAVIRIN | 4.0 | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4637514 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4637078 | — | EC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4636374 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4648991 | — | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4634271 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL1643 | RIBAVIRIN | EC50 | = | 33000.0 | nM | 4.48 |