Assay Detail
Functional
CHEMBL4611692
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Cytotoxicity against human OVCAR3 cells assessed as inhibition of cell viability incubated for 72 hrs by MTS assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | OVCAR-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cytotoxic and non-cytotoxic cardiac glycosides isolated from the combined flowers, leaves, and twigs of Streblus asper.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.31 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.82 |
| CHEMBL449686 | STREBLOSIDE | — | 1 | 6.89 |
| CHEMBL4073120 | — | — | 1 | 6.21 |
| CHEMBL4648754 | — | — | 1 | - |
| CHEMBL4647504 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL449686 | STREBLOSIDE | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4073120 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL4648754 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4647504 | — | IC50 | > | 20000.0 | nM | - |