Assay Detail
Binding
CHEMBL4613136
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDE1C2 (147 to 531 residues) (unknown origin) using [3H]-cGMP substrate incubated for 15 mins by liquid scintillation counting method
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (CHEMBL4619) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Novel Selective and Orally Bioavailable Phosphodiesterase-1 Inhibitors for the Efficient Treatment of Idiopathic Pulmonary Fibrosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.75 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4639341 | — | — | 1 | 9.05 |
| CHEMBL4640793 | — | — | 1 | 8.82 |
| CHEMBL4647278 | — | — | 1 | 8.59 |
| CHEMBL4644729 | — | — | 1 | 8.54 |
| CHEMBL4649493 | — | — | 1 | 8.33 |
| CHEMBL4639286 | — | — | 1 | 7.70 |
| CHEMBL4638381 | — | — | 1 | 7.57 |
| CHEMBL4642557 | — | — | 1 | 7.24 |
| CHEMBL4634240 | — | — | 1 | 7.19 |
| CHEMBL4632429 | — | — | 1 | 6.80 |
| CHEMBL4636141 | — | — | 1 | 6.61 |
| CHEMBL4632723 | — | — | 1 | 6.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4639341 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4640793 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4647278 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4644729 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4649493 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL4639286 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4638381 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4642557 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4634240 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4632429 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL4636141 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL4632723 | — | IC50 | = | 258.0 | nM | 6.59 |