Compound Detail
CHEMBL4636141
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Basic Information
| ChEMBL ID | CHEMBL4636141 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XIMMQQRUYYGBED-INIZCTEOSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
419.5
MW (Da)
4.71
ALogP
6
HBA
1
HBD
64.7
PSA (Ų)
0.51
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.61
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C CHEMBL4619 | IC50 | 6.61 | 6.61 | 245.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C | IC50 | = | 245.0 | nM | 6.61 | Inhibition of PDE1C2 (147 to 531 residues) (unknown origin) using [3H]-cGMP subs... | 32603117 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32603117 | 10.1021/acs.jmedchem.0c00711 | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C | 1 |
Data from ChEMBL 36 via Core Engine