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Assay Detail

CHEMBL4613567

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HL-60
Confidence 1 — Organism
Curated By Autocuration

Target

HL-60 (CHEMBL383)
Type CELL-LINE
Organism Homo sapiens

Publication

Quinolone hybrids and their anti-cancer activities: An overview.
Gao F, Zhang X, Wang T, Xiao J.
Eur J Med Chem (2019) 165 : 59 -79
PubMed 30660827 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 7.52 7.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4645895 1 7.75
CHEMBL4633435 1 7.50
CHEMBL4647394 1 7.50
CHEMBL4636122 1 7.50
CHEMBL4649384 1 7.50
CHEMBL4647558 1 7.50
CHEMBL4640038 1 7.50
CHEMBL4640200 1 7.50
CHEMBL4632631 1 7.50
CHEMBL4638094 1 7.50
CHEMBL4637492 1 7.50
CHEMBL4634909 1 7.50
CHEMBL4636149 1 7.50
CHEMBL4633427 1 7.50
CHEMBL4639575 1 7.50
CHEMBL481 IRINOTECAN 4.0 1 7.50
CHEMBL8 CIPROFLOXACIN 4.0 1 -
CHEMBL9 NORFLOXACIN 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4645895 IC50 = 18.0 nM 7.75
CHEMBL4633435 IC50 = 32.0 nM 7.50
CHEMBL4647394 IC50 = 32.0 nM 7.50
CHEMBL4636122 IC50 = 32.0 nM 7.50
CHEMBL4649384 IC50 = 32.0 nM 7.50
CHEMBL4647558 IC50 = 32.0 nM 7.50
CHEMBL4640038 IC50 = 32.0 nM 7.50
CHEMBL4640200 IC50 = 32.0 nM 7.50
CHEMBL4632631 IC50 = 32.0 nM 7.50
CHEMBL4638094 IC50 = 32.0 nM 7.50
CHEMBL4637492 IC50 = 32.0 nM 7.50
CHEMBL4634909 IC50 = 32.0 nM 7.50
CHEMBL4636149 IC50 = 32.0 nM 7.50
CHEMBL4633427 IC50 = 32.0 nM 7.50
CHEMBL4639575 IC50 = 32.0 nM 7.50
CHEMBL481 IRINOTECAN IC50 = 32.0 nM 7.50
CHEMBL8 CIPROFLOXACIN IC50 > 302.0 nM -
CHEMBL9 NORFLOXACIN IC50 > 302.0 nM -