Assay Detail
Binding
CHEMBL4614014
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]citalopram from SERT in Sprague-Dawley rat midbrain membranes incubated for 60 mins by microbeta scintillation counting method
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Midbrain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structure-Activity Relationships for a Series of (Bis(4-fluorophenyl)methyl)sulfinyl Alkyl Alicyclic Amines at the Dopamine Transporter: Functionalizing the Terminal Nitrogen Affects Affinity, Selectivity, and Metabolic Stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 5.32 | 6.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4640372 | — | — | 1 | 6.90 |
| CHEMBL4634263 | — | — | 1 | 6.21 |
| CHEMBL4643955 | — | — | 1 | 6.09 |
| CHEMBL4643859 | — | — | 1 | 5.97 |
| CHEMBL4645855 | — | — | 1 | 5.96 |
| CHEMBL4635958 | — | — | 1 | 5.86 |
| CHEMBL4647914 | — | — | 1 | 5.86 |
| CHEMBL4635589 | — | — | 1 | 5.85 |
| CHEMBL4640772 | — | — | 1 | 5.79 |
| CHEMBL4638203 | — | — | 1 | 5.60 |
| CHEMBL4639814 | — | — | 1 | 5.59 |
| CHEMBL4643380 | — | — | 1 | 5.59 |
| CHEMBL4647283 | — | — | 1 | 5.55 |
| CHEMBL4638977 | — | — | 1 | 5.41 |
| CHEMBL4636336 | — | — | 1 | 5.35 |
| CHEMBL4645184 | — | — | 1 | 4.94 |
| CHEMBL4642082 | — | — | 1 | 4.91 |
| CHEMBL4634934 | — | — | 1 | 4.88 |
| CHEMBL4648300 | — | — | 1 | 4.84 |
| CHEMBL4636778 | — | — | 1 | 4.83 |
| CHEMBL4647200 | — | — | 1 | 4.81 |
| CHEMBL4641869 | — | — | 1 | 4.76 |
| CHEMBL4633748 | — | — | 1 | 4.73 |
| CHEMBL4634776 | — | — | 1 | 4.72 |
| CHEMBL4640152 | — | — | 1 | 4.70 |
| CHEMBL4649604 | — | — | 1 | 4.67 |
| CHEMBL1373 | MODAFINIL | 4.0 | 1 | 4.50 |
| CHEMBL4647526 | — | — | 1 | 4.09 |
| CHEMBL4648586 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4640372 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL4634263 | — | Ki | = | 621.0 | nM | 6.21 |
| CHEMBL4643955 | — | Ki | = | 813.0 | nM | 6.09 |
| CHEMBL4643859 | — | Ki | = | 1060.0 | nM | 5.97 |
| CHEMBL4645855 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL4635958 | — | Ki | = | 1370.0 | nM | 5.86 |
| CHEMBL4647914 | — | Ki | = | 1390.0 | nM | 5.86 |
| CHEMBL4635589 | — | Ki | = | 1420.0 | nM | 5.85 |
| CHEMBL4640772 | — | Ki | = | 1610.0 | nM | 5.79 |
| CHEMBL4638203 | — | Ki | = | 2490.0 | nM | 5.60 |
| CHEMBL4639814 | — | Ki | = | 2570.0 | nM | 5.59 |
| CHEMBL4643380 | — | Ki | = | 2540.0 | nM | 5.59 |
| CHEMBL4647283 | — | Ki | = | 2840.0 | nM | 5.55 |
| CHEMBL4638977 | — | Ki | = | 3940.0 | nM | 5.41 |
| CHEMBL4636336 | — | Ki | = | 4480.0 | nM | 5.35 |
| CHEMBL4645184 | — | Ki | = | 11600.0 | nM | 4.94 |
| CHEMBL4642082 | — | Ki | = | 12300.0 | nM | 4.91 |
| CHEMBL4634934 | — | Ki | = | 13063.0 | nM | 4.88 |
| CHEMBL4648300 | — | Ki | = | 14600.0 | nM | 4.84 |
| CHEMBL4636778 | — | Ki | = | 14800.0 | nM | 4.83 |
| CHEMBL4647200 | — | Ki | = | 15590.0 | nM | 4.81 |
| CHEMBL4641869 | — | Ki | = | 17400.0 | nM | 4.76 |
| CHEMBL4633748 | — | Ki | = | 18700.0 | nM | 4.73 |
| CHEMBL4634776 | — | Ki | = | 19200.0 | nM | 4.72 |
| CHEMBL4640152 | — | Ki | = | 19760.0 | nM | 4.70 |
| CHEMBL4649604 | — | Ki | = | 21300.0 | nM | 4.67 |
| CHEMBL1373 | MODAFINIL | Ki | = | 31300.0 | nM | 4.50 |
| CHEMBL4647526 | — | Ki | = | 81500.0 | nM | 4.09 |
| CHEMBL4648586 | — | Ki | = | 200000.0 | nM | - |