Assay Detail
Binding
CHEMBL4618315
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NanoBRET kinase tracer K4 binding to full-length human C-terminal NanoLuc-tagged p38alpha MAPK expressed in HEK293T cells incubated for 2 hrs by NanoBRET NanoGlo substrate based NanoBRET assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Bioisosteric Replacement of Arylamide-Linked Spine Residues with N-Acylhydrazones and Selenophenes as a Design Strategy to Novel Dibenzosuberone Derivatives as Type I 1/2 p38α MAP Kinase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.04 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2316207 | FS-694 | — | 1 | 8.37 |
| CHEMBL4646557 | — | — | 1 | 8.31 |
| CHEMBL4640746 | — | — | 1 | 8.20 |
| CHEMBL4645084 | — | — | 1 | 7.81 |
| CHEMBL4642910 | — | — | 1 | 7.52 |
| CHEMBL4648755 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2316207 | FS-694 | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL4646557 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL4640746 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL4645084 | — | IC50 | = | 15.5 | nM | 7.81 |
| CHEMBL4642910 | — | IC50 | = | 30.4 | nM | 7.52 |
| CHEMBL4648755 | — | IC50 | - | — | - |