Compound Detail
CHEMBL4648755
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O=C(NCCN1CCOCC1)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)c(NC(=O)c4cccs4)c3)cc1CC2
Basic Information
| ChEMBL ID | CHEMBL4648755 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZTHHPUKKLZGEGN-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
598.7
MW (Da)
5.27
ALogP
7
HBA
3
HBD
99.8
PSA (Ų)
0.26
QED
2
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 CHEMBL260 | IC50 | 7.92 | 7.645 | 12.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 | IC50 | = | 12.0 | nM | 7.92 | Inhibition of recombinant human full-length N-terminal GST-tagged p38alpha MAPK ... | 32462866 |
| Mitogen-activated protein kinase 14 | IC50 | = | 43.0 | nM | 7.37 | Inhibition of p38alpha MAPK in human whole blood assessed as reduction in LPS-in... | 32462866 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32462866 | 10.1021/acs.jmedchem.0c00508 | Mitogen-activated protein kinase 14 | 4 |
Data from ChEMBL 36 via Core Engine