Assay Detail
Binding
CHEMBL4618316
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of p38alpha MAPK in human whole blood assessed as reduction in LPS-induced TNFalpha production preincubated for 2.5 hrs followed by LPS stimulation by ELISA
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Bioisosteric Replacement of Arylamide-Linked Spine Residues with N-Acylhydrazones and Selenophenes as a Design Strategy to Novel Dibenzosuberone Derivatives as Type I 1/2 p38α MAP Kinase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.00 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2316207 | FS-694 | — | 1 | 7.42 |
| CHEMBL4648755 | — | — | 1 | 7.37 |
| CHEMBL4640746 | — | — | 1 | 7.33 |
| CHEMBL4646557 | — | — | 1 | 7.00 |
| CHEMBL4645084 | — | — | 1 | 6.56 |
| CHEMBL4642910 | — | — | 1 | 6.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2316207 | FS-694 | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4648755 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4640746 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4646557 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL4645084 | — | IC50 | = | 276.0 | nM | 6.56 |
| CHEMBL4642910 | — | IC50 | = | 490.0 | nM | 6.31 |