Assay Detail
ADMET
CHEMBL4619044
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Inhibition of human CYP3A4
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of an Atropisomeric PI3Kβ Selective Inhibitor through Optimization of the Hinge Binding Motif.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.11 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4634167 | — | — | 1 | 6.00 |
| CHEMBL4637136 | — | — | 1 | 4.72 |
| CHEMBL4647791 | — | — | 1 | 4.62 |
| CHEMBL4639252 | — | — | 1 | - |
| CHEMBL4470860 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4634167 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4637136 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL4647791 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL4639252 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4470860 | — | IC50 | > | 25000.0 | nM | - |