Assay Detail
Functional
CHEMBL4619354
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Antiproliferative activity against human T47D cells assessed as reduction in cell viability
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of GNE-149 as a Full Antagonist and Efficient Degrader of Estrogen Receptor alpha for ER+ Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.70 | 9.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4447340 | — | — | 1 | 9.54 |
| CHEMBL4649161 | — | — | 1 | 9.16 |
| CHEMBL1358 | FULVESTRANT | 4.0 | 1 | 8.52 |
| CHEMBL3581693 | BRILANESTRANT | 2.0 | 1 | 7.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4447340 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL4649161 | — | IC50 | = | 0.69 | nM | 9.16 |
| CHEMBL1358 | FULVESTRANT | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3581693 | BRILANESTRANT | IC50 | = | 27.0 | nM | 7.57 |