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Assay Detail

CHEMBL4620216

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human carbonic anhydrase 5A using p-nitrophenyl acetate as substrate by UV-VIS spectrophotometric analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Carbonic anhydrase 5A, mitochondrial (CHEMBL4789)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design, synthesis & biological evaluation of ferulic acid-based small molecule inhibitors against tumor-associated carbonic anhydrase IX.
Aneja B, Queen A, Khan P, Shamsi F, Hussain A, Hasan P, Rizvi MMA, Daniliuc CG, Alajmi MF, Mohsin M, Hassan MI, Abid M.
Bioorg Med Chem (2020) 28 : 115424 -115424
PubMed 32209296 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.52 7.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL20 ACETAZOLAMIDE 4.0 1 7.16
CHEMBL4640224 1 5.96
CHEMBL4642019 1 5.79
CHEMBL4636417 1 5.71
CHEMBL4632515 1 5.70
CHEMBL4641337 1 5.70
CHEMBL4639923 1 5.66
CHEMBL4641693 1 5.66
CHEMBL4635469 1 5.63
CHEMBL4640484 1 5.56
CHEMBL4641866 1 5.42
CHEMBL4642730 1 5.30
CHEMBL4635834 1 5.18
CHEMBL4641975 1 5.08
CHEMBL32749 FERULATE -1.0 1 5.05
CHEMBL4647534 1 4.99
CHEMBL4637712 1 4.95
CHEMBL4632577 1 4.79
CHEMBL4649491 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL20 ACETAZOLAMIDE IC50 = 69.0 nM 7.16
CHEMBL4640224 IC50 = 1100.0 nM 5.96
CHEMBL4642019 IC50 = 1630.0 nM 5.79
CHEMBL4636417 IC50 = 1930.0 nM 5.71
CHEMBL4632515 IC50 = 1990.0 nM 5.70
CHEMBL4641337 IC50 = 1980.0 nM 5.70
CHEMBL4639923 IC50 = 2170.0 nM 5.66
CHEMBL4641693 IC50 = 2170.0 nM 5.66
CHEMBL4635469 IC50 = 2360.0 nM 5.63
CHEMBL4640484 IC50 = 2780.0 nM 5.56
CHEMBL4641866 IC50 = 3780.0 nM 5.42
CHEMBL4642730 IC50 = 4970.0 nM 5.30
CHEMBL4635834 IC50 = 6670.0 nM 5.18
CHEMBL4641975 IC50 = 8320.0 nM 5.08
CHEMBL32749 FERULATE IC50 = 8860.0 nM 5.05
CHEMBL4647534 IC50 = 10330.0 nM 4.99
CHEMBL4637712 IC50 = 11360.0 nM 4.95
CHEMBL4632577 IC50 = 16220.0 nM 4.79
CHEMBL4649491 IC50 > 20000.0 nM -