Assay Detail
ADMET
CHEMBL4621294
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Inhibition of recombinant human CYP2C9 expressed in baculovirus infected insect cell microsomes using vivid BOMF as substrate preincubated for 10 mins followed by substrate addition and measured after 25 mins in presence of NAD+ by fluorescence assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Structural Optimization of 4-(Aminomethyl)benzamides as Potent Entry Inhibitors of Ebola and Marburg Virus Infections.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.06 | 5.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4634276 | — | — | 1 | 5.35 |
| CHEMBL4640931 | — | — | 1 | 5.10 |
| CHEMBL4640955 | — | — | 1 | 4.73 |
| CHEMBL4644544 | — | — | 1 | - |
| CHEMBL4648334 | — | — | 1 | - |
| CHEMBL4640843 | — | — | 1 | - |
| CHEMBL4645609 | — | — | 1 | - |
| CHEMBL4645123 | — | — | 1 | - |
| CHEMBL4633085 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4634276 | — | IC50 | = | 4490.0 | nM | 5.35 |
| CHEMBL4640931 | — | IC50 | = | 7940.0 | nM | 5.10 |
| CHEMBL4640955 | — | IC50 | = | 18600.0 | nM | 4.73 |
| CHEMBL4644544 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4648334 | — | IC50 | - | — | - | |
| CHEMBL4640843 | — | IC50 | - | — | - | |
| CHEMBL4645609 | — | IC50 | - | — | - | |
| CHEMBL4645123 | — | IC50 | - | — | - | |
| CHEMBL4633085 | — | IC50 | - | — | - |