Assay Detail
Toxicity
CHEMBL4621668
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Toxicity in human THP1 cells assessed as reduction in cell viability
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent <i>In Vitro</i> Antileishmanial Activity: Initial SAR and Assessment of <i>In Vivo</i> Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 36 | 4.67 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4645906 | — | — | 1 | 5.30 |
| CHEMBL221027 | — | — | 1 | 5.20 |
| CHEMBL523303 | — | — | 1 | 4.50 |
| CHEMBL4632697 | — | — | 1 | 4.50 |
| CHEMBL4644580 | — | — | 1 | 4.40 |
| CHEMBL4639773 | — | — | 1 | 4.40 |
| CHEMBL522630 | — | — | 1 | 4.40 |
| CHEMBL4646679 | — | — | 1 | - |
| CHEMBL4635260 | — | — | 1 | - |
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | - |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | - |
| CHEMBL4648588 | — | — | 1 | - |
| CHEMBL4649578 | — | — | 1 | - |
| CHEMBL4648421 | — | — | 1 | - |
| CHEMBL4645046 | — | — | 1 | - |
| CHEMBL3290936 | — | — | 1 | - |
| CHEMBL4642833 | — | — | 1 | - |
| CHEMBL4648017 | — | — | 1 | - |
| CHEMBL4639318 | — | — | 1 | - |
| CHEMBL4646137 | — | — | 1 | - |
| CHEMBL4644369 | — | — | 1 | - |
| CHEMBL4639444 | — | — | 1 | - |
| CHEMBL4644356 | — | — | 1 | - |
| CHEMBL4633833 | — | — | 1 | - |
| CHEMBL254316 | RALTEGRAVIR | 4.0 | 1 | - |
| CHEMBL4644400 | — | — | 1 | - |
| CHEMBL4648046 | — | — | 1 | - |
| CHEMBL4645383 | — | — | 1 | - |
| CHEMBL4645520 | — | — | 1 | - |
| CHEMBL4634437 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4645906 | — | EC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL221027 | — | EC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL523303 | — | EC50 | = | 31622.78 | nM | 4.50 |
| CHEMBL4632697 | — | EC50 | = | 31622.78 | nM | 4.50 |
| CHEMBL4644580 | — | EC50 | = | 39810.72 | nM | 4.40 |
| CHEMBL4639773 | — | EC50 | = | 39810.72 | nM | 4.40 |
| CHEMBL522630 | — | EC50 | = | 39810.72 | nM | 4.40 |
| CHEMBL4648588 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL4635381 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL4649578 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL4648421 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL4645046 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL3290936 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL4642833 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL4648017 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL4635260 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL4648127 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL4633980 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL4632762 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL4644468 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL4644333 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL125 | MILTEFOSINE | EC50 | > | 50118.72 | nM | - |
| CHEMBL267345 | AMPHOTERICIN B | EC50 | > | 1000.0 | nM | - |
| CHEMBL4646679 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL4639318 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL4646137 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL4644369 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL4639444 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL4644356 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL4633833 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL254316 | RALTEGRAVIR | EC50 | > | 50118.72 | nM | - |
| CHEMBL4644400 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL4648046 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL4645383 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL4645520 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL4634437 | — | EC50 | > | 50118.72 | nM | - |