Assay Detail
Functional
CHEMBL4622623
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Antiviral activity against Ebolavirus infected in human HeLa cells assessed as reduction in viral replication incubated for 48 hrs by luminescence based assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Ebolavirus |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Toward the Target: Tilorone, Quinacrine, and Pyronaridine Bind to Ebola Virus Glycoprotein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.00 | 6.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL35228 | PYRONARIDINE | 3.0 | 1 | 6.09 |
| CHEMBL7568 | QUINACRINE | 4.0 | 1 | 5.98 |
| CHEMBL47298 | TILORONE | 2.0 | 1 | 5.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL35228 | PYRONARIDINE | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL7568 | QUINACRINE | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL47298 | TILORONE | IC50 | = | 1140.0 | nM | 5.94 |