Assay Detail
Functional
CHEMBL4623862
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Analgesic activity in po dosed Slc:ddY mouse model of partial spinal nerve ligation assessed as reduction in thermal hyperalgesia measured at 60 mins by paw thermal stimulator method
5
Total Activities
2
Compounds Tested
4
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of DS-1971a, a Potent, Selective Na<sub>V</sub>1.7 Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| ED50 | 2 | - | - |
| Activity | 1 | - | - |
| EC50 | 1 | 7.47 | 7.47 |
| fEC50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4633566 | DS-1971 | 2.0 | 4 | 7.47 |
| CHEMBL2325014 | PF-05089771 | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4633566 | DS-1971 | EC50 | = | 33.6 | nM | 7.47 |
| CHEMBL2325014 | PF-05089771 | ED50 | = | 3.0 | mg.kg-1 | - |
| CHEMBL4633566 | DS-1971 | Activity | - | — | - | |
| CHEMBL4633566 | DS-1971 | ED50 | = | 0.32 | mg.kg-1 | - |
| CHEMBL4633566 | DS-1971 | fEC50 | = | 1.1 | nM | - |