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Assay Detail

CHEMBL4625239

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

D(1A) dopamine receptor (CHEMBL2056)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and dopamine receptor pharmacological evaluations on ring C ortho halogenated 1-phenylbenzazepines.
Giri R, Namballa HK, Sarker A, Alberts I, Harding WW.
Bioorg Med Chem Lett (2020) 30 : 127305 -127305
PubMed 32631525 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 7.23 8.39

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL8514 BUTACLAMOL 2.0 1 8.39
CHEMBL4643069 1 7.85
CHEMBL4643426 1 7.80
CHEMBL4635277 1 7.58
CHEMBL4649012 1 7.39
CHEMBL4643886 1 7.32
CHEMBL4647167 1 7.23
CHEMBL4636741 1 7.14
CHEMBL4640497 1 7.12
CHEMBL4642805 1 6.90
CHEMBL4637938 1 6.88
CHEMBL4633950 1 6.84
CHEMBL4635423 1 6.83
CHEMBL4645139 1 5.98

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL8514 BUTACLAMOL Ki = 4.04 nM 8.39
CHEMBL4643069 Ki = 14.0 nM 7.85
CHEMBL4643426 Ki = 16.0 nM 7.80
CHEMBL4635277 Ki = 26.0 nM 7.58
CHEMBL4649012 Ki = 41.0 nM 7.39
CHEMBL4643886 Ki = 48.3 nM 7.32
CHEMBL4647167 Ki = 59.4 nM 7.23
CHEMBL4636741 Ki = 72.0 nM 7.14
CHEMBL4640497 Ki = 76.1 nM 7.12
CHEMBL4642805 Ki = 126.4 nM 6.90
CHEMBL4637938 Ki = 132.9 nM 6.88
CHEMBL4633950 Ki = 144.6 nM 6.84
CHEMBL4635423 Ki = 147.4 nM 6.83
CHEMBL4645139 Ki = 1044.0 nM 5.98