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Compound Detail

CHEMBL4640497

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COc1cc2c(cc1O)C(c1c(Cl)cccc1Cl)CNCC2

Basic Information

ChEMBL ID CHEMBL4640497
Phase Preclinical
Structure Type MOL
InChI Key ITPDHEQZMNITSW-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

338.2
MW (Da)
3.99
ALogP
3
HBA
2
HBD
41.5
PSA (Ų)
0.87
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C17H17Cl2NO2
MW 338.23
Aromatic Rings 2
Heavy Atoms 22
NP-Likeness 0.50

Activity Summary

Ki 2 meas. best 7.59

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(1B) dopamine receptor
CHEMBL1850
Ki 7.59 7.59 25.4 1
D(1A) dopamine receptor
CHEMBL2056
Ki 7.12 7.12 76.1 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
32631525 10.1016/j.bmcl.2020.127305 D(1A) dopamine receptor 1
32631525 10.1016/j.bmcl.2020.127305 D(1B) dopamine receptor 1
32631525 10.1016/j.bmcl.2020.127305 D(2) dopamine receptor 1

Data from ChEMBL 36 via Core Engine