Assay Detail
Binding
CHEMBL4625256
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR L858R/T790M mutant (unknown origin) by ELISA
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of potent EGFR kinase inhibitors against 19D/T790M/C797S mutation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.38 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545311 | BRIGATINIB | 4.0 | 1 | 8.82 |
| CHEMBL4645434 | — | — | 1 | 8.66 |
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 8.14 |
| CHEMBL4639459 | — | — | 1 | 6.90 |
| CHEMBL4647073 | — | — | 1 | 6.85 |
| CHEMBL4649261 | — | — | 1 | 6.80 |
| CHEMBL4640686 | — | — | 1 | 6.77 |
| CHEMBL4641096 | — | — | 1 | 6.77 |
| CHEMBL4642177 | — | — | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545311 | BRIGATINIB | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4645434 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL4639459 | — | IC50 | = | 126.8 | nM | 6.90 |
| CHEMBL4647073 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL4649261 | — | IC50 | = | 156.6 | nM | 6.80 |
| CHEMBL4640686 | — | IC50 | = | 170.1 | nM | 6.77 |
| CHEMBL4641096 | — | IC50 | = | 169.3 | nM | 6.77 |
| CHEMBL4642177 | — | IC50 | = | 208.0 | nM | 6.68 |