Compound Detail
CHEMBL4641096
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CCC(=O)Nc1cc(Nc2nccc(-c3cn(CCCO)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C
Basic Information
| ChEMBL ID | CHEMBL4641096 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SXMUBPOUNKVXGB-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
545.7
MW (Da)
4.58
ALogP
9
HBA
3
HBD
107.8
PSA (Ų)
0.22
QED
1
Ro5 Violations
13
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.14
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Epidermal growth factor receptor CHEMBL203 | IC50 | 7.14 | 6.7033 | 73.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Epidermal growth factor receptor | IC50 | = | 73.0 | nM | 7.14 | Inhibition of EGFR 19D/T790M/C797S mutant (unknown origin) by ELISA | 32631532 |
| Epidermal growth factor receptor | IC50 | = | 169.3 | nM | 6.77 | Inhibition of EGFR L858R/T790M mutant (unknown origin) by ELISA | 32631532 |
| Epidermal growth factor receptor | IC50 | = | 638.4 | nM | 6.2 | Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin) by ELISA | 32631532 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32631532 | 10.1016/j.bmcl.2020.127327 | Epidermal growth factor receptor | 4 |
Data from ChEMBL 36 via Core Engine