Assay Detail
Binding
CHEMBL4625258
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR 19D/T790M/C797S mutant (unknown origin) by ELISA
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of potent EGFR kinase inhibitors against 19D/T790M/C797S mutation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.42 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545311 | BRIGATINIB | 4.0 | 1 | 8.82 |
| CHEMBL4649261 | — | — | 1 | 7.82 |
| CHEMBL4645434 | — | — | 1 | 7.75 |
| CHEMBL4647073 | — | — | 1 | 7.39 |
| CHEMBL4639459 | — | — | 1 | 7.14 |
| CHEMBL4641096 | — | — | 1 | 7.14 |
| CHEMBL4640686 | — | — | 1 | 7.09 |
| CHEMBL4642177 | — | — | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545311 | BRIGATINIB | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4649261 | — | IC50 | = | 15.3 | nM | 7.82 |
| CHEMBL4645434 | — | IC50 | = | 17.9 | nM | 7.75 |
| CHEMBL4647073 | — | IC50 | = | 40.4 | nM | 7.39 |
| CHEMBL4639459 | — | IC50 | = | 72.5 | nM | 7.14 |
| CHEMBL4641096 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4640686 | — | IC50 | = | 80.5 | nM | 7.09 |
| CHEMBL4642177 | — | IC50 | = | 663.4 | nM | 6.18 |