Assay Detail
Functional
CHEMBL4625469
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Antiproliferative activity against human DU145 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
25
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of Schizandrin derivatives as tubulin polymerization inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.88 | 5.59 |
| Inhibition | 12 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.59 |
| CHEMBL4641091 | — | — | 2 | 5.47 |
| CHEMBL253688 | SCHIZANDRIN | — | 2 | 5.27 |
| CHEMBL4632643 | — | — | 2 | 5.12 |
| CHEMBL4645198 | — | — | 2 | 5.02 |
| CHEMBL4647702 | — | — | 2 | 4.98 |
| CHEMBL4649304 | — | — | 2 | 4.78 |
| CHEMBL4636170 | — | — | 2 | 4.69 |
| CHEMBL4639927 | — | — | 2 | 4.64 |
| CHEMBL4649217 | — | — | 2 | 4.60 |
| CHEMBL4645554 | — | — | 2 | 4.59 |
| CHEMBL4634265 | — | — | 2 | 4.43 |
| CHEMBL4637040 | — | — | 2 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 2540.0 | nM | 5.59 |
| CHEMBL4641091 | — | IC50 | = | 3420.0 | nM | 5.47 |
| CHEMBL253688 | SCHIZANDRIN | IC50 | = | 5380.0 | nM | 5.27 |
| CHEMBL4632643 | — | IC50 | = | 7550.0 | nM | 5.12 |
| CHEMBL4645198 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL4647702 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL4649304 | — | IC50 | = | 16570.0 | nM | 4.78 |
| CHEMBL4636170 | — | IC50 | = | 20260.0 | nM | 4.69 |
| CHEMBL4639927 | — | IC50 | = | 22850.0 | nM | 4.64 |
| CHEMBL4649217 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL4645554 | — | IC50 | = | 25500.0 | nM | 4.59 |
| CHEMBL4634265 | — | IC50 | = | 37520.0 | nM | 4.43 |
| CHEMBL4637040 | — | IC50 | = | 50500.0 | nM | 4.30 |
| CHEMBL4636170 | — | Inhibition | - | % | - | |
| CHEMBL4649304 | — | Inhibition | - | % | - | |
| CHEMBL4634265 | — | Inhibition | - | % | - | |
| CHEMBL4649217 | — | Inhibition | - | % | - | |
| CHEMBL4645554 | — | Inhibition | - | % | - | |
| CHEMBL4639927 | — | Inhibition | - | % | - | |
| CHEMBL4637040 | — | Inhibition | - | % | - | |
| CHEMBL4641091 | — | Inhibition | - | % | - | |
| CHEMBL4632643 | — | Inhibition | - | % | - | |
| CHEMBL4645198 | — | Inhibition | - | % | - | |
| CHEMBL253688 | SCHIZANDRIN | Inhibition | - | % | - | |
| CHEMBL4647702 | — | Inhibition | - | % | - |