Assay Detail
ADMET
CHEMBL4628529
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ovine COX1 using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition and measured after 2 mins by EIA
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.22 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 7.40 |
| CHEMBL1034 | DICLOFENAC SODIUM | 4.0 | 1 | 5.42 |
| CHEMBL4633930 | — | — | 1 | 5.38 |
| CHEMBL4633586 | — | — | 1 | 5.27 |
| CHEMBL4634111 | — | — | 1 | 5.22 |
| CHEMBL4637840 | — | — | 1 | 5.21 |
| CHEMBL4649049 | — | — | 1 | 5.15 |
| CHEMBL4640385 | — | — | 1 | 5.09 |
| CHEMBL4637009 | — | — | 1 | 5.01 |
| CHEMBL4648858 | — | — | 1 | 4.97 |
| CHEMBL4642268 | — | — | 1 | 4.97 |
| CHEMBL4644150 | — | — | 1 | 4.93 |
| CHEMBL4639025 | — | — | 1 | 4.91 |
| CHEMBL4647794 | — | — | 1 | 4.88 |
| CHEMBL4643407 | — | — | 1 | 4.88 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 4.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1034 | DICLOFENAC SODIUM | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4633930 | — | IC50 | = | 4170.0 | nM | 5.38 |
| CHEMBL4633586 | — | IC50 | = | 5330.0 | nM | 5.27 |
| CHEMBL4634111 | — | IC50 | = | 5970.0 | nM | 5.22 |
| CHEMBL4637840 | — | IC50 | = | 6230.0 | nM | 5.21 |
| CHEMBL4649049 | — | IC50 | = | 7110.0 | nM | 5.15 |
| CHEMBL4640385 | — | IC50 | = | 8140.0 | nM | 5.09 |
| CHEMBL4637009 | — | IC50 | = | 9840.0 | nM | 5.01 |
| CHEMBL4648858 | — | IC50 | = | 10650.0 | nM | 4.97 |
| CHEMBL4642268 | — | IC50 | = | 10610.0 | nM | 4.97 |
| CHEMBL4644150 | — | IC50 | = | 11710.0 | nM | 4.93 |
| CHEMBL4639025 | — | IC50 | = | 12410.0 | nM | 4.91 |
| CHEMBL4647794 | — | IC50 | = | 13220.0 | nM | 4.88 |
| CHEMBL4643407 | — | IC50 | = | 13210.0 | nM | 4.88 |
| CHEMBL118 | CELECOXIB | IC50 | = | 14700.0 | nM | 4.83 |