Assay Detail
Binding
CHEMBL4629883
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human MLK3 using myelin basic protein as substrate in presence of [gamma-33P]-ATP by hotspot kinase assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase 11 (CHEMBL2708) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity <i>in Vivo</i> Mouse Model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.98 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1835063 | — | — | 1 | 7.28 |
| CHEMBL4635883 | — | — | 1 | 5.56 |
| CHEMBL4640712 | — | — | 1 | 5.11 |
| CHEMBL4648967 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1835063 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL4635883 | — | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL4640712 | — | IC50 | = | 7860.0 | nM | 5.11 |
| CHEMBL4648967 | — | IC50 | > | 10000.0 | nM | - |