Assay Detail
Binding
CHEMBL4629886
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human full-length His-tagged CAMK1D expressed in baculovirus expression system using autocamtide-2 as substrate preincubated for 15 mins followed by ATP addition and measured after 2 hrs by ADP-glo luminescence assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Calcium/calmodulin-dependent protein kinase type 1D (CHEMBL5073) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity <i>in Vivo</i> Mouse Model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.89 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4635883 | — | — | 1 | 8.10 |
| CHEMBL4633229 | — | — | 1 | 7.66 |
| CHEMBL4632457 | — | — | 1 | 7.57 |
| CHEMBL4640712 | — | — | 1 | 7.51 |
| CHEMBL4644948 | — | — | 1 | 7.33 |
| CHEMBL4640492 | — | — | 1 | 7.02 |
| CHEMBL4640445 | — | — | 1 | 7.00 |
| CHEMBL4634851 | — | — | 1 | 6.94 |
| CHEMBL1835063 | — | — | 1 | 6.73 |
| CHEMBL4632574 | — | — | 1 | 6.56 |
| CHEMBL471901 | — | — | 1 | 6.37 |
| CHEMBL4639597 | — | — | 1 | 6.34 |
| CHEMBL4644912 | — | — | 1 | 6.31 |
| CHEMBL4642539 | — | — | 1 | 6.07 |
| CHEMBL4640950 | — | — | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4635883 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4633229 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4632457 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4640712 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4644948 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4640492 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL4640445 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL4634851 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL1835063 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL4632574 | — | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL471901 | — | IC50 | = | 432.0 | nM | 6.37 |
| CHEMBL4639597 | — | IC50 | = | 455.0 | nM | 6.34 |
| CHEMBL4644912 | — | IC50 | = | 485.0 | nM | 6.31 |
| CHEMBL4642539 | — | IC50 | = | 851.0 | nM | 6.07 |
| CHEMBL4640950 | — | IC50 | = | 1350.0 | nM | 5.87 |