Assay Detail
Functional
CHEMBL4666229
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anticancer activity against human DU-145 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Pyranocarbazole derivatives as potent anti-cancer agents triggering tubulin polymerization stabilization induced activation of caspase-dependent apoptosis and downregulation of Akt/mTOR in breast cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 4.54 | 5.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4785995 | — | — | 1 | 5.12 |
| CHEMBL786 | TAMOXIFEN CITRATE | 4.0 | 1 | 4.95 |
| CHEMBL4788145 | — | — | 1 | 4.44 |
| CHEMBL4756640 | — | — | 1 | 4.32 |
| CHEMBL4760705 | — | — | 1 | 4.25 |
| CHEMBL4752610 | — | — | 1 | 4.16 |
| CHEMBL4747972 | — | — | 1 | - |
| CHEMBL4781975 | — | — | 1 | - |
| CHEMBL4758896 | — | — | 1 | - |
| CHEMBL4785117 | — | — | 1 | - |
| CHEMBL4749329 | — | — | 1 | - |
| CHEMBL4756222 | — | — | 1 | - |
| CHEMBL4747612 | — | — | 1 | - |
| CHEMBL4746389 | — | — | 1 | - |
| CHEMBL4764555 | — | — | 1 | - |
| CHEMBL4780732 | — | — | 1 | - |
| CHEMBL2035835 | CLAULANSINE F | — | 1 | - |
| CHEMBL4777848 | — | — | 1 | - |
| CHEMBL4795902 | — | — | 1 | - |
| CHEMBL4762745 | — | — | 1 | - |
| CHEMBL4742668 | — | — | 1 | - |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4785995 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL786 | TAMOXIFEN CITRATE | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL4788145 | — | IC50 | = | 36600.0 | nM | 4.44 |
| CHEMBL4756640 | — | IC50 | = | 47600.0 | nM | 4.32 |
| CHEMBL4760705 | — | IC50 | = | 55700.0 | nM | 4.25 |
| CHEMBL4752610 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL4747972 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4781975 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4758896 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4785117 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4749329 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4756222 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4747612 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4746389 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4764555 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4780732 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2035835 | CLAULANSINE F | IC50 | > | 100000.0 | nM | - |
| CHEMBL4777848 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4795902 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4762745 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4742668 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL53463 | DOXORUBICIN | IC50 | - | — | - |