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Assay Detail

CHEMBL4668026

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Trypanocidal activity activity against Trypanosoma cruzi Tulahuen C4 assessed as reduction in parasite viability
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma cruzi
Confidence 1 — Organism
Curated By Autocuration

Target

Trypanosoma cruzi (CHEMBL368)
Type ORGANISM
Organism Trypanosoma cruzi

Publication

Discovery and characterization of trypanocidal cysteine protease inhibitors from the 'malaria box'.
Pereira GAN,da Silva EB,Braga SFP,Leite PG,Martins LC,Vieira RP,Soh WT,Villela FS,Costa FMR,Ray D,de Andrade SF,Brandstetter H,Oliveira RB,Caffrey CR,Machado FS,Ferreira RS
Eur J Med Chem (2019) 179 : 765 -778
PubMed 31284086 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 4.97 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4793916 1 6.00
CHEMBL597248 1 5.82
CHEMBL527541 1 5.72
CHEMBL527730 1 5.41
CHEMBL602552 1 5.26
CHEMBL2028048 1 4.88
CHEMBL580140 1 4.80
CHEMBL531738 1 4.77
CHEMBL591128 1 4.75
CHEMBL546168 1 4.64
CHEMBL529603 1 4.50
CHEMBL582420 1 4.50
CHEMBL532015 1 4.50
CHEMBL529874 1 4.50
CHEMBL533921 1 4.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4793916 IC50 = 1000.0 nM 6.00
CHEMBL597248 IC50 = 1500.0 nM 5.82
CHEMBL527541 IC50 = 1900.0 nM 5.72
CHEMBL527730 IC50 = 3900.0 nM 5.41
CHEMBL602552 IC50 = 5500.0 nM 5.26
CHEMBL2028048 IC50 = 13300.0 nM 4.88
CHEMBL580140 IC50 = 15700.0 nM 4.80
CHEMBL531738 IC50 = 16900.0 nM 4.77
CHEMBL591128 IC50 = 17800.0 nM 4.75
CHEMBL546168 IC50 = 22900.0 nM 4.64
CHEMBL529603 IC50 = 32000.0 nM 4.50
CHEMBL582420 IC50 = 32000.0 nM 4.50
CHEMBL532015 IC50 = 32000.0 nM 4.50
CHEMBL529874 IC50 = 32000.0 nM 4.50
CHEMBL533921 IC50 = 32000.0 nM 4.50