Assay Detail
Binding
CHEMBL4668307
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Inhibition of jack bean urease assessed as reduction in ammonia production using urea as substrate incubated for 15 mins by indophenol method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canavalia ensiformis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Developing new hybrid scaffold for urease inhibition based on carbazole-chalcone conjugates: Synthesis, assessment of therapeutic potential and computational docking analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.83 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4776100 | — | — | 1 | 5.16 |
| CHEMBL4760175 | — | — | 1 | 5.05 |
| CHEMBL4778537 | — | — | 1 | 4.85 |
| CHEMBL260876 | THIOUREA | — | 1 | 4.68 |
| CHEMBL4796023 | — | — | 1 | 4.61 |
| CHEMBL4779235 | — | — | 1 | 4.61 |
| CHEMBL4777883 | — | — | 1 | - |
| CHEMBL4784552 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4776100 | — | IC50 | = | 6880.0 | nM | 5.16 |
| CHEMBL4760175 | — | IC50 | = | 8930.0 | nM | 5.05 |
| CHEMBL4778537 | — | IC50 | = | 14150.0 | nM | 4.85 |
| CHEMBL260876 | THIOUREA | IC50 | = | 20800.0 | nM | 4.68 |
| CHEMBL4796023 | — | IC50 | = | 24680.0 | nM | 4.61 |
| CHEMBL4779235 | — | IC50 | = | 24780.0 | nM | 4.61 |
| CHEMBL4777883 | — | IC50 | = | 149020.0 | nM | - |
| CHEMBL4784552 | — | IC50 | = | 149900.0 | nM | - |