Assay Detail
Binding
CHEMBL4669818
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Inhibition of ROCK1 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH peptide substrate by caliper assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a phenylpyrazole amide ROCK inhibitor as a tool molecule for in vivo studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 8.00 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4114628 | — | — | 1 | 9.10 |
| CHEMBL4791701 | — | — | 1 | 9.10 |
| CHEMBL3913336 | — | — | 1 | 9.05 |
| CHEMBL4753754 | — | — | 1 | 8.51 |
| CHEMBL4764401 | — | — | 1 | 8.37 |
| CHEMBL3960736 | — | — | 1 | 8.30 |
| CHEMBL4746508 | — | — | 1 | 8.27 |
| CHEMBL3907133 | — | — | 1 | 8.27 |
| CHEMBL4111518 | — | — | 1 | 8.22 |
| CHEMBL4756156 | — | — | 1 | 8.19 |
| CHEMBL3951271 | — | — | 1 | 8.17 |
| CHEMBL4114533 | — | — | 1 | 8.15 |
| CHEMBL4741358 | — | — | 1 | 8.14 |
| CHEMBL3955445 | — | — | 1 | 8.10 |
| CHEMBL4111655 | — | — | 1 | 8.06 |
| CHEMBL4783577 | — | — | 1 | 8.00 |
| CHEMBL4109840 | — | — | 1 | 8.00 |
| CHEMBL4780269 | — | — | 1 | 7.85 |
| CHEMBL4799221 | — | — | 1 | 7.82 |
| CHEMBL4757844 | — | — | 1 | 7.80 |
| CHEMBL4784425 | — | — | 1 | 7.68 |
| CHEMBL4799704 | — | — | 1 | 7.62 |
| CHEMBL4749675 | — | — | 1 | 7.32 |
| CHEMBL4740106 | — | — | 1 | 7.25 |
| CHEMBL3951573 | — | — | 1 | 6.74 |
| CHEMBL4111347 | — | — | 1 | 5.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4114628 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4791701 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL3913336 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4753754 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL4764401 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL3960736 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4746508 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL3907133 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL4111518 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4756156 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL3951271 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL4114533 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL4741358 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL3955445 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL4111655 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL4783577 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4109840 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4780269 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4799221 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4757844 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4784425 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4799704 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4749675 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL4740106 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL3951573 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL4111347 | — | IC50 | = | 1170.0 | nM | 5.93 |