Assay Detail
Binding
CHEMBL4670027
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Inhibition of equine BuChE by Ellman's method
7
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and in vitro evaluation of vanillin derivatives as multi-target therapeutics for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.08 | 6.57 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4750099 | — | — | 1 | 6.57 |
| CHEMBL4800008 | — | — | 1 | 6.43 |
| CHEMBL4742047 | — | — | 1 | 6.05 |
| CHEMBL4778539 | — | — | 1 | 5.82 |
| CHEMBL278020 | NEOSTIGMINE | 4.0 | 1 | 5.53 |
| CHEMBL4788422 | — | — | 1 | - |
| CHEMBL13883 | VANILLIN | -1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4750099 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4800008 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4742047 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4778539 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL278020 | NEOSTIGMINE | IC50 | = | 2930.0 | nM | 5.53 |
| CHEMBL4788422 | — | IC50 | - | — | - | |
| CHEMBL13883 | VANILLIN | Inhibition | - | % | - |