Assay Detail
Binding
CHEMBL4672977
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant arginase 2 expressed in Escherichia coli using thioarginine by Ellman's assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Arginase Inhibitors for Treating Cancer and Respiratory Inflammatory Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.80 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4745275 | — | — | 1 | 8.40 |
| CHEMBL4757930 | — | — | 1 | 7.82 |
| CHEMBL4752391 | — | — | 1 | 7.68 |
| CHEMBL4753285 | — | — | 1 | 7.68 |
| CHEMBL4778086 | — | — | 1 | 7.62 |
| CHEMBL4750174 | — | — | 1 | 7.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4745275 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4757930 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4752391 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4753285 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4778086 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4750174 | — | IC50 | = | 24.0 | nM | 7.62 |