Compound Detail
CHEMBL4745275
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Basic Information
| ChEMBL ID | CHEMBL4745275 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XMBOQSCEOFRXBH-WCBMZHEXSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
244.1
MW (Da)
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Arginase-2, mitochondrial CHEMBL1795148 | IC50 | 8.4 | 8.4 | 4.0 | 1 |
| Arginase-1 CHEMBL1075097 | IC50 | 7.52 | 7.52 | 30.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Arginase-2, mitochondrial | IC50 | = | 4.0 | nM | 8.4 | Inhibition of human recombinant arginase 2 expressed in Escherichia coli using t... | 33335657 |
| Arginase-1 | IC50 | = | 30.0 | nM | 7.52 | Inhibition of human recombinant arginase 1 expressed in Escherichia coli using t... | 33335657 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33335657 | 10.1021/acsmedchemlett.0c00593 | Arginase-1 | 1 |
| 33335657 | 10.1021/acsmedchemlett.0c00593 | Arginase-2, mitochondrial | 1 |
Data from ChEMBL 36 via Core Engine