Assay Detail
Binding
CHEMBL4673674
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Inhibition of human GOAT expressed in HEK293 cells harboring -preproghrelin in presence of Octanoate-BSA incubated for 5 hr by ELISA
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent progress in the discovery of ghrelin O-acyltransferase (GOAT) inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 10.11 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4793203 | — | — | 1 | 10.70 |
| CHEMBL4746798 | — | — | 1 | 10.55 |
| CHEMBL4754865 | — | — | 1 | 10.18 |
| CHEMBL4781133 | — | — | 1 | 9.89 |
| CHEMBL4789143 | — | — | 1 | 9.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4793203 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL4746798 | — | IC50 | = | 0.028 | nM | 10.55 |
| CHEMBL4754865 | — | IC50 | = | 0.066 | nM | 10.18 |
| CHEMBL4781133 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL4789143 | — | IC50 | = | 0.56 | nM | 9.25 |