Compound Detail
CHEMBL4746798
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Basic Information
| ChEMBL ID | CHEMBL4746798 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PEMOKRBTCSJWJN-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
375.3
MW (Da)
2.83
ALogP
8
HBA
1
HBD
108.5
PSA (Ų)
0.59
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 10.55
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Ghrelin O-acyltransferase CHEMBL3588729 | IC50 | 10.55 | 10.55 | 0.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 10.55 | 10.55 | 0.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Ghrelin O-acyltransferase | IC50 | = | 0.028 | nM | 10.55 | Inhibition of human GOAT expressed in HEK293 cells harboring -preproghrelin in p... | 33479618 |
| Unchecked | IC50 | = | 0.028 | nM | 10.55 | Pharmacological Activity: Each assay plate contains wells with vehicle controls ... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33479618 | 10.1039/d0md00210k | Ghrelin O-acyltransferase | 1 |
Data from ChEMBL 36 via Core Engine